VaccineChecking
Back to all destinations

Sao Tome and Principe

Standard Coverage

Central Africa • STP

Last updated: May 26, 2026

Travel Information
AI-Generated

Sao Tome and Principe is an idyllic island nation located in the Gulf of Guinea, renowned for its pristine beaches, lush rainforests, and rich volcanic landscapes. It offers a tranquil escape for nature lovers and adventurers seeking an off-the-beaten-path destination with vibrant Creole culture.

Visa Requirements

Visa-Free for Many Nationalities

Citizens of the EU, USA, Canada, and several other countries are exempt from visa requirements for stays of up to 15 days.

Typically Required Documents

  • Passport valid for at least six months
  • Return or onward flight ticket
  • Proof of accommodation
  • Yellow fever vaccination certificate if arriving from an endemic area

Popular Attractions

1

Obo National Park offers incredible biodiversity, trekking trails, and the iconic Pico Cao Grande, a massive volcanic spire rising from the jungle.

2

Ilheu das Rolas is a tiny equatorial island that features a monument marking the equator and offers stunning snorkeling in crystal-clear waters.

3

Boca do Inferno is a dramatic coastal site where waves surge through a blowhole, creating a spectacular display of the power of the Atlantic Ocean.

4

The historical Roça Sundy is a former cocoa plantation that provides a glimpse into the colonial history and agricultural roots of the country.

5

Praia Banana is frequently cited as one of the most beautiful beaches in the world, known for its golden sand and dense, lush vegetation.

Local Customs & Etiquette

Greetings are important, so a polite 'Bom dia' (good morning) or 'Boa tarde' (good afternoon) is expected when entering shops or interacting with locals.

Dress modestly in villages and towns, keeping beachwear strictly to the coastline rather than in urban or religious settings.

Ask for permission before taking photographs of people or local homes, as it is considered respectful and polite.

The pace of life is relaxed, so expect a 'mora' (slow) approach to service in restaurants and shops, requiring patience.

Tipping is not mandatory but is highly appreciated in restaurants and for tour guides as a gesture of gratitude for good service.

Safety Tips

Sao Tome and Principe is generally considered very safe, but it is wise to avoid walking alone on isolated beaches after dark.

Keep your valuables and passport in a hotel safe and carry only small amounts of cash while exploring.

Ensure you have adequate travel insurance that covers emergency medical evacuation, as local healthcare facilities are limited.

Drink only bottled or treated water to avoid waterborne illnesses common in tropical regions.

Take precautions against mosquito bites by wearing long-sleeved clothing and using reliable insect repellent to prevent malaria.

Always use reputable guides when hiking in the rainforest to avoid getting lost in dense, unmarked terrain.

AI-generated content. Visa requirements vary by nationality — verify with the official embassy before travel.

Entry Requirements

Yellow Fever

Source: CDC

Not Required

Not required when traveling directly from non-risk countries.

View source

Yellow Fever

Source: CDC

Required

A yellow fever vaccination certificate is required for travelers over 9 months of age arriving from countries with risk of yellow fever transmission.

View source

Malaria Chemoprophylaxis

Source: CDC

Required

CDC recommends that travelers going to São Tomé and Príncipe take prescription medicine to prevent malaria. Depending on the medicine you take, you will need to start taking this medicine multiple days before your trip, as well as during and after your trip. Talk to your doctor about which malaria medication you should take.

View source

Hepatitis A

Source: CDC

Required

Recommended for unvaccinated travelers one year old or older going to São Tomé and Príncipe. Infants 6 to 11 months old should also be vaccinated against Hepatitis A. The dose does not count toward the routine 2-dose series.

View source

Hepatitis B

Source: CDC

Required

Recommended for unvaccinated travelers of all ages traveling to São Tomé and Príncipe.

View source
Recommended Vaccines & Precautions

Core Vaccines

Tdap (tetanus, diphtheria, pertussis)

Source: CDC

All ages

Ensure routine vaccinations are up-to-date before travel.

View source

Hepatitis A

Source: CDC

All ages

Recommended due to potential exposure through contaminated food or water.

View source

MMR (measles, mumps, rubella)

Source: CDC

All ages

Ensure routine vaccinations are up-to-date before travel.

View source

Food and water safety precautions

Source: CDC

All ages

To reduce the risk of foodborne and waterborne illnesses.

View source

COVID-19 vaccination

Source: CDC

All ages

Staying up to date with COVID-19 vaccinations helps reduce the risk of severe illness during travel.

View source

Insect bite prevention

Source: CDC

All ages

To prevent diseases transmitted by insects, such as malaria and dengue fever.

View source

Routine vaccines (MMR, Tdap, etc.)

Source: CDC

All ages

Ensure all routine vaccinations are up to date before travel.

View source

Measles-Mumps-Rubella (MMR) Vaccine

Source: CDC

All ages

All international travelers should be fully vaccinated against measles with the MMR vaccine, including an early dose for infants 6–11 months, according to CDC’s measles vaccination recommendations for international travel.

Cases of measles are on the rise worldwide. Travelers are at risk of measles if they have not been fully vaccinated at least two weeks prior to departure, or have not had measles in the past, and travel internationally to areas where measles is spreading.

View source

Meningococcal vaccination

Source: CDC

All ages

Consider vaccination against meningococcal disease especially if visiting crowded places.

View source

Insect bite prevention measures

Source: CDC

All ages

To prevent mosquito bites, use insect repellent and wear long sleeves and pants, especially during dusk and dawn.

View source

Routine vaccinations (MMR, Tdap, etc.)

Source: CDC

All ages

Make sure you are up-to-date on routine vaccines before every trip.

View source

For Most Travelers

Insect bite prevention (DEET), including malaria prevention measures

Source: CDC

All ages

Recommended to reduce risk of insect-borne diseases.

View source

Update routine vaccines

Source: CDC

All ages

Ensure you are protected against diseases such as measles, mumps, rubella, and diphtheria, especially in areas with outbreaks.

View source

Dengue vaccine

Source: CDC

child

If you have had dengue in the past, vaccination can help prevent future infections, especially if traveling to areas with a high risk of dengue.

View source

Insect bite prevention

Source: CDC

All ages

To prevent malaria and dengue fever, which are transmitted through insect bites.

View source

Practice food and water safety

Source: CDC

All ages

To avoid gastrointestinal illnesses when consuming local foods and drinks.

View source

Typhoid

Source: CDC

All ages

Recommended for travelers with potential exposure to contaminated food or water.

View source

Hepatitis A

Source: CDC

All ages

Recommended for most travelers to protect against hepatitis A.

View source

Itinerary-Specific

COVID-19 vaccines

Source: CDC

All ages

Recommended for all eligible travelers to protect against COVID-19.

View source

Hepatitis B

Source: CDC

All ages

Consider vaccination for travelers who may have sexual contact, be exposed to blood, or need medical treatment.

View source

Vaccines for other diseases as advised by health professionals

Source: CDC

All ages

Consult a healthcare provider for personalized advice depending on travel itineraries.

View source

COVID-19 vaccination

Source: CDC

All ages

To protect against COVID-19, which remains a health risk.

View source

Rabies

Source: CDC

All ages

Consider if you will be in contact with animals or in areas without quick access to medical care.

View source

Food and water safety precautions

Source: CDC

All ages

Be cautious with food and water to reduce the risk of illness during travel.

View source

Malaria prophylaxis (Atovaquone-proguanil, doxycycline or mefloquine)

Source: CDC

All ages

Malaria is a risk in certain areas, especially during the rainy season; prophylaxis is recommended for most travelers.

View source
Malaria Information

Risk Area: No malaria risk

View source

Risk Area: Entire country

Chemoprophylaxis: Atovaquone-proguanil, doxycycline, or mefloquine

Seasonality: June to October

View source

Risk Area: All areas of São Tomé and Príncipe

Chemoprophylaxis: Atovaquone-proguanil, doxycycline, mefloquine, tafenoquine

Seasonality: Year-round

View source